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3625 Missouri Blvd Jefferson City, MO 65109 (573) 893-7676
3625 Missouri Blvd, Jefferson City, MO 65109
Sales: (573)893-7676 | Service: (573)298-6688 | Parts: (573)298-6584

2021 Honda Odyssey vs. 2021 Toyota Sienna: What Are the Differences?

2021 Honda Odyssey

Two new minivans have arrived for the 2021 model year — the redesigned Honda Odyssey and all-new Toyota Sienna. If you’re undecided on which minivan is right for you, let the Honda of Jefferson City team help you compare the 2021 Odyssey with the 2021 Sienna. We looked at the 2021 Honda Odyssey Elite versus the 2021 Toyota Sienna Platinum and compared their performance, interior, exterior, technology, and safety features.

You can find the 2021 Odyssey for sale at our dealership in Jefferson City, MO. Please reach out to a Honda of Jefferson City representative online or at (573) 893-7676 with any questions.


One of the primary differences between the 2021 Honda Odyssey and 2021 Toyota Sienna is the powertrain. Every 2021 Sienna is a hybrid vehicle, while every 2021 Odyssey features a powerful V6 gas engine. While the Sienna offers all-wheel drive (AWD) and includes selectable drive modes, only the Odyssey features intelligent traction management for extra control on slick road conditions.

Browse the following chart for Odyssey and Sienna performance specs.

2021 Honda Odyssey


2021 Toyota Sienna

3.5L I-VTEC® V6


2.5L DOHC w/ permanent magnet synchronous motors

Ten-speed automatic



280 HP


245 net HP

262 lb.-ft



3,500 lbs.

Max. Towing

3,500 lbs.

Interior Comfort & Design

Both the 2021 Honda Odyssey and 2021 Toyota Sienna offer excellent interior comfort and versatility with the following similar interior features.

  • Heated and ventilated front seats
  • Leather-trimmed seats
  • Leather-wrapped steering wheel

While the Sienna includes unique features like a heated steering wheel and four-zone climate control, the 2021 Honda Odyssey takes interior convenience to the next level with the following interior features:

  • Magic Slide® second-row seats - Honda Magic Slide® second-row seats with three LATCH positions provide premier flexibility in the 2021 Odyssey. A multi-function second-row center seat allows you to maximize the number of available seats or remove it and slide the seats laterally for versatile access. Each removable seat has five stops along the Magic Slide®, with a 12.9-inch range of motion.
  • Maximum seating for eight people - The 2021 Odyssey EX trim and up features seating for eight people. By comparison, the 2021 Sienna Platinum has maximum seating for seven.
  • Eight-way power front passenger’s seat - Your co-pilot will thank you for the eight-way power front passenger’s seat in the Odyssey. The Sienna features a four-way power passenger’s seat.
  • HondaVAC® - Make short work of the crumbs, pet hair, and dirt that come with an active family life using the integrated HondaVAC® vacuum system in the Odyssey.
  • More cargo volume - In the trims we compared, the 2021 Odyssey offers up to 155.7 cubic-feet of cargo space, versus 101 cubic-feet of cargo space in the Sienna.
  • Handy storage - The 2021 Honda Odyssey helps keep your family organized with front row and cargo area bag hooks, along with a rear storage well.
  • Ambient LED lighting - Gentle blue light provides a calming cabin atmosphere and a bit of extra visibility in the Odyssey.
2021 Honda Odyssey interior

Exterior Features

The redesigned exteriors of both the 2021 Honda Odyssey and Sienna include many of the same features. LED headlights, fog lights, and tail lights; dual power sliding side doors; and a power moonroof all provide family-friendly utility to each minivan. 

The 2021 Odyssey features a standard hands-free power rear liftgate while the Sienna makes it available. The Odyssey also features 19-inch wheels, compared to standard 18-inch wheels for the Sienna.

Technology Features

Stay connected and keep all your passengers entertained in both the 2021 Honda Odyssey and 2021 Toyota Sienna. In the top trims we compared, the Odyssey is equipped with a standard advanced rear entertainment system — an available feature on the Sienna. Other similar technology features in both vehicles include:

  • Wireless device charger
  • Apple CarPlay® and Android Auto™
  • Wi-Fi® hotspot
  • USB ports (seven in Sienna, five in Odyssey)
  • 12V power outlets (one in Sienna, three in Odyssey)
  • In-car public address system
  • Navigation system

The 2021 Sienna does have a 10-inch head-up display and 9-inch center touchscreen — compared with an 8-inch center touchscreen in the Odyssey. The sound systems in each model include a 12-speaker JBL® system in the Sienna, and a 550-watt premium audio system with 11 speakers in the Odyssey.

Unique Odyssey technology features include:

2021 Honda Odyssey tech

Safety Features

Take the safety of your and your passengers seriously in both the 2021 Honda Odyssey and 2021 Toyota Sienna. Toyota Safety Sense™ 2.0, ten airbags, and a birds-eye view camera have your back in the Sienna. The Odyssey includes the Honda Sensing® suite of driver assist features with the exclusive Collision Mitigation Braking System™ in addition to the occupant safety ring.